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Human Organs-on-Chips as replacements for animal testing with Donald Ingber

No more mice and no more human testing subjects! How great could life be? But, can Organs-on-a-Chip actually replace human organs? And what human organ functions can Organs-on-Chips be used to model? Plus, how effective are organs-on-chips at modeling human diseases and drug responses? Further, why is there a need to replace animal testing for drug development, should we care about mice? Can Organs-on-Chips be used for specific people, as in the making of personalised medicine?Organs-on-Chips are micro devices made out of living human cells and created with computer chip manufacturing techniques. Their applications are immense: they can be used for drug development, to investigate how organs work as well as to make personalised medicine. Donald Ingber, world leading biology engineer from the Wyss Institute for Biologically Inspired Engineering at Harvard will explain the recent advances in the engineering of multiple organ chips, including lung, intestine, kidney, and blood-brain barrier chips, as well as how they have been used to develop human disease models, co-culture living microbiome, and discover new therapeutics. Donald Ingber will also discuss recent efforts in joining all of these organ chips and forming a complete ‘human-body-on-chips’, therefore creating an instrument that can be used to study cellular responses to pharmaceuticals, chemicals and toxins.

Post Series: Tennessee
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